Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13449688 | 0.94 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13449710 | 0.93 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL15472845 | 0.92 | MAPT (0.51) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13449709 | 0.92 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL11890507 | 0.91 | MAPT (0.54) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL15441559 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13449707 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL2582550 | 0.90 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13449705 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTMEN1 | |
| SCHEMBL13449690 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11419856-B2 | Pharmaceutical combinations for use in the treatment of neoplastic diseases | Basilea Pharmaceutica International AG (CH) | 2022-08-23 | — | — | US | disclosed |
| US-20220031670-A1 | PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES | BASILEA PHARM INT AG (CH) | 2022-02-03 | — | — | US | disclosed |
| US-20200390749-A1 | PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES | BASILEA PHARM INT AG (CH) | 2020-12-17 | — | — | US | disclosed |
| US-20200237730-A1 | NOVEL DOSAGE PRINCIPLE FOR DRUGS USEFUL FOR TREATING NEOPLASTIC DISEASES | Basilea Pharmaceutica International AG (CH) | 2020-07-30 | — | — | US | disclosed |
| US-10724072-B2 | Use of phospho-Akt as a biomarker of drug response | BASILEA PHARMACEUTICA AG (CH) | 2020-07-28 | — | — | US | disclosed |
| US-10656162-B2 | Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2020-05-19 | — | — | US | disclosed |
| US-10222377-B2 | Use of BUBR1 as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2019-03-05 | — | — | US | disclosed |
| US-9995754-B2 | Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2018-06-12 | — | — | US | disclosed |
| US-9995754-B2 | Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2018-06-12 | — | — | US | disclosed |
| US-9970938-B2 | Use of BUBR1 as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2018-05-15 | — | — | US | disclosed |
| EP-2666014-B1 | USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2016-10-05 | — | — | EP | disclosed |
| US-9366682-B2 | Use of stathmin as a biomarker of drug response to furazanobenzimidazoles | BASILEA PHARMACEUTICA AG (CH) | 2016-06-14 | — | — | US | disclosed |
| EP-2459553-B1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | BASILEA PHARMACEUTICA AG (CH) | 2014-10-01 | — | — | EP | disclosed |
| US-8802858-B2 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases | BASILEA PHARMACEUTICA AG (CH) | 2014-08-12 | — | — | US | disclosed |
| US-8802858-B2 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases | BASILEA PHARMACEUTICA AG (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20140080872-A1 | USE OF PHOSPHO-AKT AS A BIOMARKER OF DRUG RESPONSE | BASILEA PHARMACEUTICA AG (CH) | 2014-03-20 | — | — | US | disclosed |
| US-20140045897-A1 | USE OF BUBR1 AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2014-02-13 | — | — | US | disclosed |
| US-20140024686-A1 | USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2014-01-23 | — | — | US | disclosed |
| US-20140024686-A1 | USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | BASILEA PHARMACEUTICA AG (CH) | 2014-01-23 | — | — | US | disclosed |
| US-20120264792-A1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | BASILEA PHARMACEUTICA AG | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10724072-B2 | Use of phospho-Akt as a biomarker of drug response | AKT3, AKT1S1, AKT2 | ALDH1A1 4829/4885KDM4E 3884/4885HSD17B10 2197/4885 |
| US-20120264792-A1 | FURAZANOBENZIMIDAZOLES AS PRODRUGS TO TREAT NEOPLASTIC OR AUTOIMMUNE DISEASES | SSB, VHL, AHR | ALDH1A1 838/4885KDM4E 926/4885HSD17B10 701/4885 |
| US-10656162-B2 | Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles | TUBB, TUBB1, TUBB6 | ALDH1A1 1153/4885KDM4E 4206/4885HSD17B10 2199/4885 |
| US-20140024686-A1 | USE OF GLU-TUBULIN AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | TUBB, TUBB1, TUBB6 | ALDH1A1 1153/4885KDM4E 4206/4885HSD17B10 2199/4885 |
| US-20140045897-A1 | USE OF BUBR1 AS A BIOMARKER OF DRUG RESPONSE TO FURAZANOBENZIMIDAZOLES | BUB1B, BUB1, BUB3 | ALDH1A1 1640/4885KDM4E 2211/4885HSD17B10 1484/4885 |
| US-20200390749-A1 | PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES | ERLIN1, EDNRB, ERLIN2 | ALDH1A1 838/4885KDM4E 4438/4885HSD17B10 894/4885 |
| US-11419856-B2 | Pharmaceutical combinations for use in the treatment of neoplastic diseases | ERLIN1, EDNRB, ERLIN2 | ALDH1A1 838/4885KDM4E 4438/4885HSD17B10 894/4885 |
| US-10222377-B2 | Use of BUBR1 as a biomarker of drug response to furazanobenzimidazoles | BUB1B, BUB1, BUB3 | ALDH1A1 1640/4885KDM4E 2211/4885HSD17B10 1484/4885 |
| US-20200237730-A1 | NOVEL DOSAGE PRINCIPLE FOR DRUGS USEFUL FOR TREATING NEOPLASTIC DISEASES | SLC10A1, SLC10A2, SLC5A11 | ALDH1A1 846/4885KDM4E 2492/4885HSD17B10 853/4885 |
| US-20220031670-A1 | PHARMACEUTICAL COMBINATIONS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES | KRAS, GLS, SLC28A1 | ALDH1A1 358/4885KDM4E 4124/4885HSD17B10 2025/4885 |
| US-20140080872-A1 | USE OF PHOSPHO-AKT AS A BIOMARKER OF DRUG RESPONSE | AKT3, AKT1S1, AKT2 | ALDH1A1 4641/4885KDM4E 2928/4885HSD17B10 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.