Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13450242 | 0.90 | EPHX2 (0.62) | EPHX2METHDAC1HDAC6MAPK8 | |
| SCHEMBL13450240 | 0.84 | EPHX2 (0.58) | EPHX2ROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL13450259 | 0.82 | EPHX2 (0.55) | EPHX2ROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL13450238 | 0.81 | L3MBTL1 (0.58) | EPHX2ROCK2HDAC1HDAC6NAMPT | |
| SCHEMBL13450264 | 0.81 | EPHX2 (0.57) | EPHX2ROCK2ROCK1METHDAC1 | |
| SCHEMBL13450865 | 0.80 | ROCK2 (0.55) | EPHX2ROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL13450263 | 0.77 | EPHX2 (0.53) | EPHX2ROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL10323294 | 0.77 | KDM4E (0.53) | EPHX2ROCK2ROCK1METCHRM4 | |
| SCHEMBL10448104 | 0.77 | ROCK2 (0.51) | ROCK2ROCK1METCHRM4HTR7 | |
| SCHEMBL13450258 | 0.76 | POLB (0.67) | EPHX2ROCK2ROCK1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |