Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839197 | 0.84 | SMN1; SMN2 (0.68) | LMNAKMT2AMAPTTHRBNPC1 | |
| SCHEMBL4560251 | 0.83 | MAPT (0.70) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL14413878 | 0.82 | HTT (0.74) | LMNAMEN1KMT2AMAPTTHRB | |
| SCHEMBL13841263 | 0.82 | LMNA (0.81) | LMNAMEN1KMT2AMAPTTHRB | |
| SCHEMBL11837576 | 0.81 | ALOX5 (0.69) | LMNAKMT2AMAPTTHRBNPC1 | |
| SCHEMBL19174458 | 0.80 | KDM4E (0.54) | LMNAMEN1KMT2AMAPTTHRB | |
| SCHEMBL2404352 | 0.79 | POLB (0.59) | LMNAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL30916891 | 0.79 | KDM4E (0.60) | LMNAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL10115710 | 0.79 | LMNA (0.46) | LMNAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL10116051 | 0.79 | CACNA1H (0.50) | LMNAKMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773796-B1 | OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-03-03 | — | — | EP | disclosed |