Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.34 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633050 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL16214812 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL1832401 | 0.85 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL9909462 | 0.85 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL1832400 | 0.85 | ALDH1A1 (0.40) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL12525570 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL12524607 | 0.84 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL3026458 | 0.82 | MAPT (0.49) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL3026456 | 0.82 | MAPT (0.49) | ALDH1A1MAPTPOLBMAPK1GAA | |
| SCHEMBL19974399 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTPOLBMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877733-B2 | 1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20120263678-A1 | 1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120263678-A1 | 1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | PNP, NUDT1, TYMP | ALDH1A1 1076/4885MAPT 4260/4885POLB 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.