Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | GSK3A | P49840 | 3/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910620 | 0.90 | GSK3B (0.36) | GSK3BGSK3AKAT2BCDK1CYP2D6 | |
| SCHEMBL2909549 | 0.89 | GSK3B (0.39) | GSK3BGSK3AKAT2BCDK1CYP2D6 | |
| SCHEMBL2912527 | 0.89 | GSK3B (0.36) | GSK3BGSK3AKAT2BCDK1CYP2D6 | |
| SCHEMBL2908407 | 0.87 | GSK3B (0.34) | GSK3BGSK3AKAT2BCDK1CYP2D6 | |
| SCHEMBL2910651 | 0.85 | MAPT (0.36) | — | |
| SCHEMBL2907410 | 0.85 | GSK3B (0.34) | GSK3BGSK3AKAT2BCDK1CYP2D6 | |
| SCHEMBL2912926 | 0.85 | BDKRB1 (0.34) | GSK3BGSK3AKAT2B | |
| SCHEMBL2904688 | 0.85 | GSK3B (0.34) | GSK3BGSK3AKAT2BCDK1 | |
| SCHEMBL2904612 | 0.85 | GSK3B (0.36) | GSK3BGSK3AKAT2BCDK1CCNB2 | |
| SCHEMBL2907498 | 0.83 | RAB9A (0.38) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671049-B2 | Pyrrole based inhibitors of glycogen synthase kinase 3 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-03-02 | — | — | US | disclosed |