Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 6/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345420 | 0.78 | DDAH1 (0.47) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1345153 | 0.78 | DDAH1 (0.52) | DDAH1NOS1NOS3NOS2MEN1 | |
| SCHEMBL1345589 | 0.77 | DPP7 (0.42) | DDAH1DPP7GNAI3GNAO1GNAI1 | |
| SCHEMBL15165700 | 0.75 | DPP7 (0.51) | DDAH1NOS1DPP7GNAI3GNAO1 | |
| SCHEMBL1343488 | 0.75 | DDAH1 (0.43) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1343529 | 0.75 | DDAH1 (0.53) | DDAH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1345238 | 0.74 | DDAH1 (0.44) | DDAH1DPP7GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1345052 | 0.74 | DDAH1 (0.43) | DDAH1NOS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1343296 | 0.74 | DDAH1 (0.43) | DDAH1NOS1DPP7GRIN2DGRIN3B | |
| SCHEMBL1345488 | 0.74 | DDAH1 (0.73) | DDAH1NOS1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828109-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2013-06-05 | — | — | EP | disclosed |
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL Biomedica PLC c/o Finance Division University College of London (GB) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | DDAH1, DOHH, IMPDH1 | DDAH1 1/4885NOS1 581/4885DPP7 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.