Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | ATM | Q13315 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.70 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.64 |
| ▸ | RELA | Q04206 | 3/20 | 0.64 |
| ▸ | CDC25A | P30304 | 1/20 | 0.63 |
| ▸ | CDC25B | P30305 | 1/20 | 0.63 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693465 | 0.98 | MAPT (0.75) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL1180215 | 0.92 | MAPT (0.84) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL19196285 | 0.91 | CYP19A1 (0.64) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL4279335 | 0.87 | MAPT (0.74) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL11464717 | 0.87 | SREBF2 (0.79) | MAPTKDM4EPOLBRAB9ASMN1; SMN2 | |
| SCHEMBL28534175 | 0.86 | KDM4E (0.75) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL4279334 | 0.86 | KDM4E (0.75) | MAPTKDM4EATMPOLBRAB9A | |
| Pyrrole SCHEMBL3654122 | 0.85 | KDM4E (0.69) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL1181045 | 0.85 | CYP19A1 (0.67) | MAPTKDM4EATMPOLBRAB9A | |
| SCHEMBL1180576 | 0.85 | CYP19A1 (0.71) | MAPTKDM4EATMPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168576-A2 | New utilities of tricyclic compounds | Shionogi & Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318958-A1 | New utilities of tricyclic compounds | APOB, PON1, APOL1 | MAPT 4593/4885KDM4E 4138/4885ATM 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.