Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458152 | 0.89 | HDAC1 (0.53) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL13458404 | 0.85 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL2638719 | 0.84 | HDAC1 (0.49) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL2638720 | 0.84 | HDAC1 (0.49) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL2638769 | 0.83 | HDAC1 (0.48) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL2638771 | 0.83 | HDAC1 (0.48) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL9976632 | 0.82 | EGFR (0.43) | HDAC1HDAC3HDAC8HDAC2HDAC6 | |
| SCHEMBL2640070 | 0.82 | HDAC1 (0.58) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL2640068 | 0.82 | HDAC1 (0.58) | HDAC1HDAC3HDAC8HDAC4MEF2D | |
| SCHEMBL8028680 | 0.79 | HDAC1 (0.60) | HDAC1HDAC3HDAC4MEF2DHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031708-A2 | NOVEL ORTHO-AMINOANILIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |