Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966578 | 0.86 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL1966406 | 0.86 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL3226190 | 0.85 | TRPA1 (0.41) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL3226203 | 0.85 | TRPA1 (0.41) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL13458154 | 0.85 | HDAC1 (0.54) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL1965849 | 0.84 | HDAC1 (0.62) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL10039319 | 0.84 | HDAC1 (0.50) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL10039317 | 0.83 | HDAC1 (0.48) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL1964921 | 0.82 | HDAC1 (0.63) | HDAC1HDAC3HDAC8HDAC4HDAC2 | |
| SCHEMBL1964918 | 0.82 | HDAC1 (0.63) | HDAC1HDAC3HDAC8HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031708-A2 | NOVEL ORTHO-AMINOANILIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |