Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.56 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | EP300 | Q09472 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978891 | 0.86 | HDAC1 (0.60) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL3228591 | 0.85 | EGFR (0.71) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL3228583 | 0.85 | EGFR (0.71) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL2640602 | 0.82 | HDAC1 (0.66) | HDAC1MMP1MMP2MMP9EGFR | |
| SCHEMBL7978520 | 0.81 | HDAC1 (0.64) | HDAC1MMP1MMP2MMP9EGFR | |
| SCHEMBL4536420 | 0.80 | TRPA1 (0.68) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL8348482 | 0.80 | TRPA1 (0.68) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL13180844 | 0.80 | HDAC1 (0.74) | HDAC1HDAC4MMP1MMP2MMP9 | |
| SCHEMBL4536422 | 0.80 | TRPA1 (0.68) | HDAC1HDAC4MEF2DMMP1MMP2 | |
| SCHEMBL28633277 | 0.80 | HDAC1 (0.63) | HDAC1MMP1MMP2MMP9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095324-A1 | NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-06 | — | — | WO | disclosed |