Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 4/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | HCK | P08631 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459839 | 0.90 | RAF1 (0.52) | BRAFRAF1CSF1RMAPK14SMN1; SMN2 | |
| SCHEMBL13459819 | 0.89 | CSF1R (0.50) | TEKBRAFRAF1CSF1RKDR | |
| SCHEMBL13459602 | 0.84 | NTRK1 (0.52) | BRAFRAF1CSF1RKDRABL1 | |
| SCHEMBL13459942 | 0.82 | NR2E1 (0.56) | TEKBRAFRAF1CSF1RLYN | |
| SCHEMBL13459944 | 0.78 | CSF1R (0.55) | CSF1RKDRNTRK1FLT3 | |
| SCHEMBL13459840 | 0.74 | BRAF (0.53) | BRAFRAF1CSF1RKDRABL1 | |
| SCHEMBL3525285 | 0.72 | ABL1 (0.68) | TEKBRAFRAF1CSF1RLYN | |
| SCHEMBL2380398 | 0.72 | EPHX2 (0.57) | KDRSMN1; SMN2 | |
| SCHEMBL4257833 | 0.71 | CSF1R (0.66) | TEKBRAFRAF1CSF1RLYN | |
| SCHEMBL3585041 | 0.71 | CSF1R (0.66) | TEKBRAFRAF1CSF1RLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032986-A2 | NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY | 주식회사 이큐스팜 (KR) | 2010-03-25 | — | — | WO | disclosed |