Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 3/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459602 | 0.90 | NTRK1 (0.52) | CSF1RFLT4FLT3PDGFRAKCNH2 | |
| SCHEMBL13459592 | 0.81 | RIPK1 (0.69) | CSF1RFLT4FLT3TRPV1KDR | |
| SCHEMBL13459840 | 0.80 | BRAF (0.53) | CSF1RFLT3KCNH2TRPV1KDR | |
| SCHEMBL13459818 | 0.79 | RET (0.64) | CSF1RFLT4FLT3PDGFRACDK2 | |
| SCHEMBL3843511 | 0.79 | KDR (0.52) | CSF1RFLT4FLT3PDGFRAKCNH2 | |
| SCHEMBL13459943 | 0.78 | TEK (0.54) | CSF1RFLT3KDRNTRK1 | |
| SCHEMBL3166302 | 0.77 | SRC (0.72) | CSF1RFLT4FLT3PDGFRAKCNH2 | |
| SCHEMBL13632604 | 0.74 | KDR (0.59) | TRPV1KDR | |
| SCHEMBL13459594 | 0.74 | HTR2B (0.53) | CSF1RFLT4FLT3TRPV1KDR | |
| SCHEMBL13459817 | 0.73 | TRPV1 (0.53) | CSF1RFLT4FLT3TRPV1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032986-A2 | NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY | 주식회사 이큐스팜 (KR) | 2010-03-25 | — | — | WO | disclosed |