Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.91 |
| ▸ | SLC6A4 | P31645 | 20/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346084 | 0.95 | HTR1A (1.00) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1346527 | 0.87 | HTR1A (0.75) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1346536 | 0.87 | HTR1A (1.00) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1346367 | 0.86 | HTR1A (0.84) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1346325 | 0.85 | HTR1A (0.77) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL27798632 | 0.82 | HTR1A (0.76) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1344325 | 0.82 | HTR1A (1.00) | HTR1ASLC6A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL1345892 | 0.81 | HTR1A (0.98) | HTR1ASLC6A4CYP2D6 | |
| Bromide SCHEMBL1347120 | 0.81 | HTR1A (0.98) | HTR1ASLC6A4CYP2D6 | |
| SCHEMBL1345881 | 0.79 | HTR1A (1.00) | HTR1ASLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232405-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | claimed |
| US-20110118312-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-05-19 | — | — | US | claimed |
| EP-2239254-A1 | BENZYLPIPERIZINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-10-13 | — | — | EP | claimed |
| US-20100113792-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-05-06 | — | — | US | claimed |
| US-20130303786-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO (JP) | 2013-11-14 | — | — | US | disclosed |
| US-8557998-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD (JP) | 2013-10-15 | — | — | US | disclosed |
| US-20120259122-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-10-11 | — | — | US | disclosed |
| US-8232405-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-8063223-B2 | Benzylpiperizine compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-11-22 | — | — | US | disclosed |
| US-20110118312-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2239254-A1 | BENZYLPIPERIZINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-10-13 | — | — | EP | disclosed |
| US-20100113792-A1 | BENZYLPIPERIZINE COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303786-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | HTR1A 39/4885SLC6A4 286/4885CYP2D6 55/4885 |
| US-20100113792-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | HTR1A 39/4885SLC6A4 286/4885CYP2D6 55/4885 |
| US-20120259122-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | HTR1A 39/4885SLC6A4 286/4885CYP2D6 55/4885 |
| US-20110118312-A1 | BENZYLPIPERIZINE COMPOUND | OPRM1, GRM1, CHRM1 | HTR1A 39/4885SLC6A4 286/4885CYP2D6 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.