Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | MAP2 | P11137 | 2/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676235 | 1.00 | JAK2 (0.52) | JAK2MAP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL678785 | 0.87 | DYRK1A (0.44) | MAP2CHEK1CLK1DYRK1ADYRK2 | |
| SCHEMBL4414274 | 0.84 | BCHE (0.50) | JAK2KDM4EHSD17B10GABRA1GABRG2 | |
| SCHEMBL675220 | 0.83 | ALK (0.48) | MAP2CSF1RMEN1KMT2AKDM4E | |
| SCHEMBL15873503 | 0.82 | CHUK (0.54) | JAK2MAP2CSF1RMEN1KMT2A | |
| SCHEMBL27841156 | 0.81 | MAP2 (0.40) | JAK2MAP2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL674243 | 0.81 | GABRA1 (0.47) | MEN1KMT2AKDM4EGABRA1GABRG2 | |
| SCHEMBL674512 | 0.80 | GABRP (0.54) | JAK2MAP2KMT2AHSD17B10GABRA1 | |
| SCHEMBL25583541 | 0.80 | MEN1 (0.58) | MAP2CSF1RMEN1KMT2AKDM4E | |
| SCHEMBL25617626 | 0.80 | MEN1 (0.58) | MAP2CSF1RMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |