Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.33 |
| ▸ | TKT | P29401 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915592 | 0.73 | EGLN2 (0.41) | EGLN2SOS2TKTNQO1CDC7 | |
| SCHEMBL3164701 | 0.73 | MEN1 (0.52) | MEN1USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL21921718 | 0.71 | ALDH1A1 (0.46) | EGLN2SOS2TKTNQO1CDC7 | |
| SCHEMBL29882642 | 0.69 | HTT (0.42) | EGLN2SOS2TKTNQO1CDC7 | |
| SCHEMBL3047995 | 0.69 | KDM4E (0.42) | EGLN2SOS2TKTNQO1CDC7 | |
| SCHEMBL16914426 | 0.69 | HTT (0.42) | EGLN2SOS2TKTNQO1CDC7 | |
| SCHEMBL24024725 | 0.69 | MEN1 (0.32) | MEN1USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL21969607 | 0.69 | MEN1 (0.42) | MEN1USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL13222949 | 0.69 | MAPT (0.38) | MEN1USP2LMNACYP1A2CYP3A4 | |
| SCHEMBL3917265 | 0.67 | CTSB (0.55) | CTSBMEN1LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687639-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-30 | — | — | US | disclosed |