Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 5/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346240 | 1.00 | CHRNA3 (0.43) | CHRNA3CHRNB2CHRNB4CHRNA4KCNH2 | |
| SCHEMBL1346242 | 1.00 | CHRNA3 (0.43) | CHRNA3CHRNB2CHRNB4CHRNA4KCNH2 | |
| SCHEMBL1346246 | 1.00 | CHRNA3 (0.43) | CHRNA3CHRNB2CHRNB4CHRNA4KCNH2 | |
| SCHEMBL1350165 | 0.92 | KHK (0.42) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1350166 | 0.92 | KHK (0.42) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1350168 | 0.92 | KHK (0.42) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1350171 | 0.92 | KHK (0.42) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1348315 | 0.91 | CHRNA3 (0.40) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1348313 | 0.91 | CHRNA3 (0.40) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 | |
| SCHEMBL1348691 | 0.88 | NPC1 (0.41) | CHRNA3CHRNB2CHRNB4CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633222-B2 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT, INC. (US) | 2014-01-21 | — | — | US | claimed |
| US-8063068-B2 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT, INC. (US) | 2011-11-22 | — | — | US | claimed |
| EP-1947100-B1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT INC (US) | 2011-07-27 | — | — | EP | claimed |
| US-20110152293-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. (US) | 2011-06-23 | — | — | US | claimed |
| JP-4663627-B2 | — | — | 2011-04-06 | — | — | JP | claimed |
| US-20100010042-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. (US) | 2010-01-14 | — | — | US | claimed |
| EP-1947100-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | Targacept, Inc. (US) | 2008-07-23 | — | — | EP | claimed |
| JP-2006519868-A | — | — | 2006-08-31 | — | — | JP | claimed |
| US-20060094732-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | SCHMITT JEFFREY D | 2006-05-04 | — | — | US | claimed |
| EP-1601670-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | Targacept Inc. (US) | 2005-12-07 | — | — | EP | claimed |
| WO-2004078752-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT INC. (US) | 2004-09-16 | — | — | WO | claimed |
| US-20040176348-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | AVENTIS PHARMA S.A. | 2004-09-09 | — | — | US | claimed |
| US-20150164894-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. | 2015-06-18 | — | — | US | disclosed |
| US-20140107164-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8633222-B2 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-8067443-B2 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | TARGACEPT, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20060094732-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | SCHMITT JEFFREY D | 2006-05-04 | — | — | US | disclosed |
| EP-1601670-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | Targacept Inc. (US) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078752-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT INC. (US) | 2004-09-16 | — | — | WO | disclosed |
| US-20040176348-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | AVENTIS PHARMA S.A. | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176348-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
| US-20110152293-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
| US-20060094732-A1 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
| US-20140107164-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
| US-20100010042-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
| US-20150164894-A1 | ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | CHRNA5, OPRK1, CHRNA6 | CHRNA3 9/4885CHRNB2 7/4885CHRNB4 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.