Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.48 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30233600 | 0.83 | HIF1A (0.53) | CNR1HIF1AMLLT1NAPEPLDLMNA | |
| SCHEMBL3507196 | 0.82 | ALDH1A1 (0.58) | CNR1HIF1AMLLT1NAPEPLDMEN1 | |
| SCHEMBL12468830 | 0.82 | CNR1 (0.49) | CNR1HIF1AMLLT1NAPEPLDNPC1 | |
| SCHEMBL12956081 | 0.78 | PARP1 (0.49) | CNR1LMNANPC1 | |
| SCHEMBL1507146 | 0.75 | POLB (0.64) | CNR1HIF1AMEN1KMT2A | |
| SCHEMBL26451554 | 0.74 | POLB (0.53) | CNR1HIF1AMEN1KMT2ACKS1B | |
| Hydrochloric Acid SCHEMBL30951167 | 0.74 | POLB (0.63) | CNR1HIF1AMEN1KMT2A | |
| SCHEMBL12469013 | 0.73 | PRKCQ (0.53) | NAPEPLDMEN1KMT2ACKS1BSKP1 | |
| SCHEMBL24151174 | 0.72 | P2RX7 (0.51) | CNR1NAPEPLD | |
| SCHEMBL30232755 | 0.72 | CNR1 (0.45) | CNR1HIF1AMLLT1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2012-10-17 | — | — | EP | disclosed |