Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.55 |
| ▸ | JAK3 | P52333 | 6/20 | 0.55 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279503 | 0.88 | JAK2 (0.64) | JAK2JAK3ZAP70HDAC1PDGFRB | |
| SCHEMBL12801350 | 0.87 | JAK2 (0.65) | JAK2JAK3HDAC1PDGFRBFLT3 | |
| SCHEMBL12800926 | 0.86 | JAK2 (0.64) | JAK2JAK3HDAC1PDGFRBFLT3 | |
| SCHEMBL12801381 | 0.80 | JAK2 (0.62) | JAK2JAK3HDAC1PDGFRBFLT3 | |
| SCHEMBL12801312 | 0.80 | JAK2 (0.62) | JAK2JAK3HDAC1PDGFRBFLT3 | |
| SCHEMBL15108156 | 0.79 | JAK2 (0.61) | JAK2JAK3ZAP70TBK1SMG1 | |
| SCHEMBL12801098 | 0.79 | JAK2 (0.76) | JAK2JAK3HDAC1JAK1TYK2 | |
| SCHEMBL1669713 | 0.78 | JAK2 (0.77) | JAK2JAK3HDAC1PDGFRBFLT3 | |
| SCHEMBL30053338 | 0.77 | ZAP70 (0.56) | JAK2JAK3ZAP70HDAC1TBK1 | |
| SCHEMBL2877271 | 0.77 | ZAP70 (0.56) | JAK2JAK3ZAP70HDAC1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |