Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.64 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.64 |
| ▸ | JAK3 | P52333 | 7/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.50 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | NEK3 | P51956 | 2/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669713 | 0.91 | JAK2 (0.77) | JAK2TBK1JAK3JAK1PDGFRB | |
| SCHEMBL12274032 | 0.88 | JAK2 (0.73) | JAK2TBK1JAK3JAK1PDGFRB | |
| SCHEMBL13467117 | 0.88 | JAK2 (0.55) | JAK2TBK1JAK3JAK1ZAP70 | |
| SCHEMBL13279889 | 0.88 | JAK2 (0.52) | JAK2TBK1JAK3JAK1ZAP70 | |
| SCHEMBL12275181 | 0.88 | JAK2 (0.72) | JAK2TBK1JAK3JAK1PDGFRB | |
| SCHEMBL12521805 | 0.88 | JAK2 (0.72) | JAK2TBK1JAK3JAK1PDGFRB | |
| SCHEMBL12522340 | 0.87 | JAK2 (0.71) | JAK2TBK1JAK3JAK1PDGFRB | |
| SCHEMBL13279912 | 0.84 | TBK1 (0.52) | JAK2TBK1PDGFRBIKBKEIKBKB | |
| SCHEMBL13279693 | 0.84 | TBK1 (0.51) | JAK2TBK1JAK3PDGFRBIKBKE | |
| SCHEMBL13279695 | 0.82 | TBK1 (0.50) | JAK2TBK1JAK3JAK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-09-25 | — | — | US | claimed |
| EP-2696683-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | Alzheimer's Institute of America, Inc. (US) | 2014-02-19 | — | — | EP | claimed |
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | claimed |
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-09-25 | — | — | US | disclosed |
| EP-2696683-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | Alzheimer's Institute of America, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012142329-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | MYREXIS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | CSNK1G1, PRKCE, PHKG1 | JAK2 396/4885TBK1 12/4885JAK3 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.