Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 12/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198057 | 0.89 | ABCB1 (0.50) | ABCB1ALDH1A1DPP4POLBMAOA | |
| SCHEMBL2353865 | 0.81 | ABCB1 (0.47) | ABCB1KDM4EDPP4MAOAMAOB | |
| SCHEMBL2353907 | 0.81 | ABCB1 (0.57) | ABCB1 | |
| SCHEMBL1719195 | 0.81 | KDM4E (0.62) | ALDH1A1KDM4EDPP4POLBMAOA | |
| SCHEMBL17035227 | 0.80 | BCHE (0.64) | ALDH1A1KDM4EPOLBBCHEPTGS2 | |
| SCHEMBL3774672 | 0.80 | ABCB1 (0.47) | ABCB1ALDH1A1DPP4POLBMAOA | |
| SCHEMBL15550275 | 0.77 | ABCB1 (0.52) | ABCB1ALDH1A1DPP4MAOAMAOB | |
| SCHEMBL23402683 | 0.76 | TSHR (0.56) | KDM4EPOLBTSHR | |
| SCHEMBL23403330 | 0.74 | BCHE (0.59) | ALDH1A1KDM4EPOLBBCHEPTGS2 | |
| SCHEMBL23400266 | 0.71 | PTGS2 (0.60) | ALDH1A1KDM4EPOLBBCHEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-B1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-10-17 | — | — | EP | disclosed |