Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482547 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL8482552 | 0.87 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL28032582 | 0.87 | POLB (0.47) | SMN1; SMN2POLBKDM4EAKR1C3ALDH1A1 | |
| SCHEMBL18280327 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL8338550 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL1399960 | 0.86 | HSD17B10 (0.63) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL7073236 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL27480514 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 | |
| SCHEMBL12328328 | 0.85 | KDM4E (0.50) | SMN1; SMN2POLBKDM4EALDH1A1HSD17B10 | |
| SCHEMBL687106 | 0.85 | KDM4E (0.53) | SMN1; SMN2POLBKDM4EAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3393467-B1 | COMPOSITIONS COMPRISING NICOTINAMIDE RIBOSIDE AND A UROLITHIN | AMAZENTIS SA (CH) | 2020-07-01 | — | — | EP | disclosed |
| US-10421720-B2 | Octahydrocyclopentapyrroles, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-09-24 | — | — | US | disclosed |
| WO-2017109195-A1 | COMPOSITIONS COMPRISING NICOTINAMIDE RIBOSIDE AND A UROLITHIN | AMAZENTIS SA (CH) | 2017-06-29 | — | — | WO | disclosed |
| CN-106414430-A | Pharmacologically active quinazolinedione derivatives | 奥赖恩公司 | 2017-02-15 | — | — | CN | disclosed |
| WO-2016008862-A1 | SUBSTITUTED VINYL AND ALKYNYL CYANOCYCLOALKANOLS AND VINYL AND ALKYNYL CYANOHETEROCYCLOALKANOLS AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-01-21 | — | — | WO | disclosed |
| WO-2012139891-A1 | SUBSTITUTED VINYL AND ALKINYL CYCLOHEXENOLS AS ACTIVE AGENTS AGAINST ABIOTIC STRESS IN PLANTS | BAYER CROPSCIENCE AG (DE) | 2012-10-18 | — | — | WO | disclosed |
| US-7446195-B2 | High affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421720-B2 | Octahydrocyclopentapyrroles, their preparation and use | CLN6, ALDH1A2, C1S | SMN1; SMN2 1454/4885POLB 1395/4885KDM4E 4528/4885 |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | CDKL2, CDK2, CDKL1 | SMN1; SMN2 2211/4885POLB 1045/4885KDM4E 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.