Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 15/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288056 | 0.95 | CTSK (0.47) | TDP1CTSKCTSSCA1CA2 | |
| SCHEMBL29506103 | 0.90 | CTSK (0.51) | CTSKCTSS | |
| SCHEMBL28523886 | 0.89 | CTSK (0.50) | CTSKCTSS | |
| SCHEMBL30901642 | 0.89 | CTSK (0.50) | CTSKCTSS | |
| SCHEMBL14279380 | 0.89 | CTSK (0.56) | CTSKCTSS | |
| SCHEMBL18644348 | 0.89 | CTSK (0.56) | CTSKCTSS | |
| SCHEMBL21660257 | 0.89 | CTSK (0.49) | TDP1CTSKCTSSCA1CA2 | |
| SCHEMBL9191203 | 0.89 | CTSK (0.49) | TDP1CTSKCTSSCA1CA2 | |
| SCHEMBL13669545 | 0.88 | CTSK (0.54) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL8042680 | 0.87 | TDP1 (0.51) | TDP1CTSKCTSSCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264738-A1 | DISPIROPYRROLIDINE DERIVATIVES | SUGIMOTO YUUICHI (JP) | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264738-A1 | DISPIROPYRROLIDINE DERIVATIVES | MDM2, TP53, TP53BP1 | TDP1 1524/4885CTSK 4518/4885CTSS 4406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.