Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.42 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18082546 | 0.90 | DPP8 (0.41) | NAMPTTPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL22874790 | 0.88 | NAMPT (0.54) | NAMPTTPSAB1TPSD1TPSG1SMYD3 | |
| SCHEMBL17546316 | 0.85 | ALDH1A1 (0.53) | NAMPTL3MBTL1TLR9TLR8TLR7 | |
| SCHEMBL22875133 | 0.84 | TPSAB1 (0.48) | NAMPTTPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL17540513 | 0.84 | NAMPT (0.42) | NAMPTTPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL13097128 | 0.83 | NAMPT (0.43) | NAMPTTPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL12522667 | 0.82 | NAMPT (0.45) | NAMPTTPSAB1TPSD1TPSG1L3MBTL1 | |
| SCHEMBL18082558 | 0.81 | ALDH1A1 (0.41) | NAMPTPOLBLMNAALDH1A1 | |
| SCHEMBL13779970 | 0.81 | NAMPT (0.45) | NAMPTL3MBTL1TSHRSMYD3ALOX15 | |
| SCHEMBL18082852 | 0.81 | NAMPT (0.44) | NAMPTL3MBTL1TSHRLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3348558-A1 | COMPOSITIONS COMPRISING FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS | Newlink Genetics Corporation (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2012142237-A1 | FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS | NEWLINK GENETICKS CORPORATION (US) | 2012-10-18 | — | — | WO | disclosed |