Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30785552 | 0.84 | CYP11B1 (0.57) | HDAC1LMNAMEN1KMT2AKDM4D | |
| SCHEMBL30785569 | 0.84 | KCNMA1 (0.64) | POLBMAPTHDAC1LMNAMEN1 | |
| SCHEMBL10097932 | 0.84 | KDM4D (0.50) | HDAC1MEN1KMT2AKDM4DKDM4C | |
| SCHEMBL16456326 | 0.84 | NAMPT (0.57) | POLBMAPTHDAC1LMNAMEN1 | |
| SCHEMBL14542346 | 0.84 | CYP11B1 (0.57) | MAPTHDAC1LMNAMEN1KMT2A | |
| SCHEMBL28561950 | 0.84 | KDM4D (0.69) | POLBHDAC1KDM4DKDM4CKCNMA1 | |
| SCHEMBL16455939 | 0.82 | RAB9A (0.59) | MAPTLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL979159 | 0.82 | MAPK1 (0.50) | MAPTHDAC1LMNAKDM4DKDM4C | |
| SCHEMBL16456356 | 0.81 | TRPV1 (0.60) | HDAC1KDM4DKDM4CKCNMA1NPC1 | |
| SCHEMBL30785584 | 0.81 | CYP11B1 (0.60) | POLBMAPTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |