Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14371524 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL12592372 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL12592377 | 1.00 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL14065595 | 0.89 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL14065597 | 0.89 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL13041171 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL13671200 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL13473844 | 0.83 | SLC6A3 (0.53) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL12592383 | 0.83 | SLC6A3 (0.53) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL13473847 | 0.83 | SLC6A3 (0.53) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293900-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators | MERCK SHARP & DOHME CORP (US) | 2012-10-23 | — | — | US | disclosed |
| US-7652024-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090325990-A1 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2009-12-31 | — | — | US | disclosed |
| US-20090253744-A1 | Acylated piperidine derivatives as melanocortin-4 receptor modulators | MERCK SHARP & DOHME CORP. | 2009-10-08 | — | — | US | disclosed |
| US-20090170863-A1 | Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators | MERCK & CO., INC. (US) | 2009-07-02 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325990-A1 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC3R | SLC6A2 254/4885SLC6A4 123/4885SLC6A3 196/4885 |
| US-20090253744-A1 | Acylated piperidine derivatives as melanocortin-4 receptor modulators | MC4R, MC5R, MC3R | SLC6A2 373/4885SLC6A4 126/4885SLC6A3 281/4885 |
| US-20090170863-A1 | Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators | MC4R, MC5R, MC3R | SLC6A2 254/4885SLC6A4 123/4885SLC6A3 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.