Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065597 | 1.00 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CHRNA7BACE1 | |
| SCHEMBL12592377 | 0.89 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRNA7BACE1 | |
| SCHEMBL13473846 | 0.89 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRNA7BACE1 | |
| SCHEMBL12592372 | 0.89 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRNA7BACE1 | |
| SCHEMBL14371524 | 0.89 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CHRNA7BACE1 | |
| SCHEMBL13671200 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL13041171 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL14065598 | 0.83 | MAPT (0.54) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL14065593 | 0.83 | MAPT (0.54) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 | |
| SCHEMBL14376312 | 0.83 | MAPT (0.54) | SLC6A2SLC6A4SLC6A3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7276520-B2 | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-7160886-B2 | Acylated piperazine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2007-01-09 | — | — | US | disclosed |