Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047188 | 0.87 | POLB (0.39) | HSD11B1GABRA5POLBSMN1; SMN2HRH3 | |
| SCHEMBL3334012 | 0.86 | HSD11B1 (0.54) | HSD11B1HSD11B2SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL13366175 | 0.77 | FAAH (0.38) | HSD11B1HRH3MEN1NPC1KMT2A | |
| SCHEMBL13474005 | 0.77 | POLB (0.39) | HSD11B1POLBSMN1; SMN2HRH3RAB9A | |
| SCHEMBL14106036 | 0.75 | NPC1 (0.51) | SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL3328670 | 0.74 | HSD11B1 (0.51) | HSD11B1RAB9AMEN1NPC1CASP3 | |
| SCHEMBL6303431 | 0.72 | NPC1 (0.43) | POLBSMN1; SMN2HRH3RAB9AMEN1 | |
| SCHEMBL6879266 | 0.71 | CHRNA7 (0.67) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL7709806 | 0.71 | CHRNA7 (0.67) | HRH3MEN1KMT2AALDH1A1 | |
| SCHEMBL12345369 | 0.71 | MAPK1 (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152081-B1 | NOVEL COMPOUNDS | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2008127924-A1 | NOVEL COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC. (US) | 2008-10-23 | — | — | WO | disclosed |