Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13477452 | 0.77 | BRS3 (0.44) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL19085137 | 0.76 | BRS3 (0.45) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL19085228 | 0.76 | BRS3 (0.47) | TNKS2BRS3ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20620494 | 0.76 | BRS3 (0.40) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL20620515 | 0.75 | BRS3 (0.40) | TNKS2BRS3ALDH1A1SMN1; SMN2CACNA1B | |
| SCHEMBL13477501 | 0.75 | NPC1 (0.48) | BRS3ALDH1A1SMN1; SMN2GAAKDM4E | |
| SCHEMBL13477541 | 0.75 | BRS3 (0.46) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL19085173 | 0.75 | BRS3 (0.44) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL20621018 | 0.75 | HTT (0.45) | TNKS2ALDH1A1SMN1; SMN2CACNA1BGAA | |
| SCHEMBL19085328 | 0.75 | BRS3 (0.42) | TNKS2BRS3ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190000832-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | Selder Pharma Inc. (US) | 2019-01-03 | — | — | US | disclosed |
| EP-2149561-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2010-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190000832-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | TNKS2 1217/4885BRS3 1/4885ALDH1A1 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.