Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 8/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13477541 | 0.83 | BRS3 (0.46) | BRS3TNKS2P2RX7KDM4EALDH1A1 | |
| SCHEMBL19085173 | 0.83 | BRS3 (0.44) | BRS3TNKS2P2RX7KDM4EALDH1A1 | |
| SCHEMBL20620973 | 0.83 | BRS3 (0.43) | BRS3TNKS2P2RX7SMN1; SMN2 | |
| SCHEMBL13477501 | 0.82 | NPC1 (0.48) | BRS3KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL19085244 | 0.82 | BRS3 (0.44) | BRS3TNKS2P2RX7KDM4EALDH1A1 | |
| SCHEMBL19085137 | 0.82 | BRS3 (0.45) | BRS3TNKS2P2RX7KDM4EALDH1A1 | |
| SCHEMBL20620580 | 0.82 | BRS3 (0.44) | BRS3TNKS2P2RX7KDM4ECYP2C9 | |
| SCHEMBL19085322 | 0.81 | BRS3 (0.44) | BRS3TNKS2KDM4ECYP2C9CYP2C19 | |
| SCHEMBL20620514 | 0.81 | BRS3 (0.44) | BRS3TNKS2P2RX7KDM4EALDH1A1 | |
| SCHEMBL19085328 | 0.81 | BRS3 (0.42) | BRS3TNKS2P2RX7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | SELDAR PHARMA INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | SELDAR PHARMA INC. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189390-A1 | TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF | BRS3, BDKRB2, NTSR2 | BRS3 1/4885TNKS2 1217/4885CDYL2 2462/4885 |
| US-10016410-B2 | Tetrahydroisoquinolin-1-one derivative or salt thereof | BRS3, BDKRB2, NTSR2 | BRS3 1/4885TNKS2 1217/4885CDYL2 2462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.