Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14623643 | 0.92 | PTGDR2 (0.46) | PTGDR2 | |
| SCHEMBL1878612 | 0.90 | PTGDR2 (0.48) | PTGDR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13478767 | 0.89 | PTGDR2 (0.47) | PTGDR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14625198 | 0.89 | PTGDR2 (0.47) | PTGDR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1877119 | 0.88 | PTGDR2 (0.47) | PTGDR2 | |
| SCHEMBL14624694 | 0.88 | PTGDR2 (0.47) | PTGDR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14624682 | 0.87 | PTGDR2 (0.45) | PTGDR2HDAC1HDAC6 | |
| SCHEMBL12637106 | 0.86 | PTGDR2 (0.46) | PTGDR2 | |
| SCHEMBL14624592 | 0.85 | PTGDR2 (0.42) | PTGDR2 | |
| SCHEMBL14623711 | 0.84 | PTGDR2 (0.48) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2007002181-A2 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | ELI LILLY AND COMPANY (US) | 2007-01-04 | — | — | WO | disclosed |