Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662372 | 0.84 | MEN1 (0.49) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6664624 | 0.83 | PSD (0.52) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6663749 | 0.83 | MAPT (0.48) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6591623 | 0.83 | KDM4E (0.55) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6668285 | 0.83 | MEN1 (0.52) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6591626 | 0.83 | KDM4E (0.55) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL16211020 | 0.82 | PSD (0.55) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL16211019 | 0.82 | PSD (0.55) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6593887 | 0.80 | MEN1 (0.82) | MEN1KMT2APOLBMAPTHPGD | |
| SCHEMBL6593893 | 0.80 | MEN1 (0.82) | MEN1KMT2APOLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659277-B2 | Ubiquitin ligase inhibitors and methods related thereto | Proteologies, Ltd. (IL) | 2010-02-09 | — | — | US | disclosed |
| US-7659277-B2 | Ubiquitin ligase inhibitors and methods related thereto | Proteologies, Ltd. (IL) | 2010-02-09 | — | — | US | disclosed |
| US-20070015768-A1 | Ubiquitin ligase inhibitors and methods related thereto | PROTEOLOGICS, LTD. (IL) | 2007-01-18 | — | — | US | disclosed |
| US-20070015768-A1 | Ubiquitin ligase inhibitors and methods related thereto | PROTEOLOGICS, LTD. (IL) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015768-A1 | Ubiquitin ligase inhibitors and methods related thereto | XIAP, NEDD4, MDM2 | MEN1 3989/4885KMT2A 604/4885POLB 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.