Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 5/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680133 | 1.00 | CHRM2 (0.42) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL8301669 | 0.79 | DPP4 (0.47) | CHRM2CHRM4CHRM5DPP4SIGMAR1 | |
| SCHEMBL3170475 | 0.79 | DPP4 (0.47) | CHRM2CHRM4CHRM5DPP4SIGMAR1 | |
| SCHEMBL24685658 | 0.74 | CHRM2 (0.45) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL1488909 | 0.74 | LTA4H (0.45) | CHRM2CHRM4CHRM5ACHEDPP4 | |
| SCHEMBL3274071 | 0.73 | DPP4 (0.45) | CHRM2CHRM4CHRM5ACHEDPP4 | |
| SCHEMBL12855709 | 0.71 | CHRM2 (0.50) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL20797832 | 0.70 | CHRM2 (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL20811168 | 0.70 | CHRM2 (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL9677809 | 0.69 | MAPT (0.44) | MAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658066-B9 | ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL MYERS SQUIBB CO (US) | 2010-02-24 | — | — | EP | disclosed |