Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146705 | 0.80 | ALDH1A1 (1.00) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL28606279 | 0.78 | PTPN1 (0.41) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL4508215 | 0.76 | ALDH1A1 (0.67) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL3029269 | 0.76 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2KDM4EKMT2AMAPT | |
| SCHEMBL28604134 | 0.75 | ALDH1A1 (0.39) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL4508936 | 0.74 | ALDH1A1 (0.63) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL11110017 | 0.74 | ALDH1A1 (0.63) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL9444249 | 0.73 | ALDH1A1 (0.61) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL15545294 | 0.73 | ALDH1A1 (0.61) | ALDH1A1PTPN1RAB9ANPC1LMNA | |
| SCHEMBL30593801 | 0.72 | ALDH1A1 (0.65) | ALDH1A1PTPN1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100028278-A1 | USE OF CHROMAN-4-ONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100028278-A1 | USE OF CHROMAN-4-ONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-02-04 | — | — | US | disclosed |
| WO-2008113450-A2 | USE OF CHROMAN-4-ON-DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100028278-A1 | USE OF CHROMAN-4-ONE DERIVATIVES | COXFA4L2, TYR, XPA | ALDH1A1 270/4885PTPN1 1766/4885RAB9A 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.