Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 8/20 | 0.50 |
| ▸ | TACR1 | P25103 | 5/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.40 |
| ▸ | MTTP | P55157 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347772 | 0.93 | SLC6A9 (0.53) | SLC6A9MTTPGAA | |
| SCHEMBL1349456 | 0.92 | SLC6A9 (0.52) | SLC6A9MTTPGAA | |
| SCHEMBL1350169 | 0.90 | SLC6A9 (0.54) | SLC6A9MTTPGAA | |
| SCHEMBL1350134 | 0.88 | SLC6A9 (0.49) | SLC6A9TACR1KCNK3 | |
| SCHEMBL1350715 | 0.88 | SLC6A9 (0.49) | SLC6A9TACR1KCNK3MTTPGAA | |
| SCHEMBL1349967 | 0.87 | SLC6A9 (0.48) | SLC6A9TACR1TACR3 | |
| SCHEMBL3264199 | 0.87 | SLC6A9 (0.47) | SLC6A9MTTP | |
| SCHEMBL1350069 | 0.85 | SLC6A9 (0.46) | SLC6A9KCNK3GAA | |
| SCHEMBL1349875 | 0.84 | SLC6A9 (0.46) | SLC6A9GAA | |
| SCHEMBL1349630 | 0.84 | SLC6A9 (0.53) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063098-B2 | GlyT1 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048531-A1 | GlyT1 RECEPTOR ANTAGONISTS | GLRA1, GLRA2, GRIA1 | SLC6A9 20/4885TACR1 102/4885KCNK3 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.