Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18233020 | 0.85 | JAK2 (0.41) | ALDH1A1HPGDTSHRLMNAMAPT | |
| SCHEMBL28454526 | 0.81 | CDK8 (0.44) | ALDH1A1HPGDTSHRLMNAMAPT | |
| SCHEMBL18233029 | 0.80 | MEN1 (0.52) | ALDH1A1TSHRLMNAMAPTSMN1; SMN2 | |
| SCHEMBL18330359 | 0.79 | LMNA (0.45) | HPGDTSHRLMNASMN1; SMN2MAPK14 | |
| SCHEMBL16591601 | 0.79 | SMN1; SMN2 (0.46) | HPGDTSHRLMNAMAPTSMN1; SMN2 | |
| SCHEMBL18415215 | 0.78 | ALDH1A1 (0.34) | ALDH1A1HPGDTSHRLMNAMAPT | |
| SCHEMBL3188434 | 0.78 | KMT2A (0.50) | LMNAMAPTSMN1; SMN2MAPK14MAPK13 | |
| SCHEMBL18236188 | 0.77 | SMN1; SMN2 (0.46) | ALDH1A1HPGDMAPTSMN1; SMN2RECQL | |
| SCHEMBL668208 | 0.77 | MAPK14 (0.60) | LMNAMAPTSMN1; SMN2MAPK14KMT2A | |
| SCHEMBL13045903 | 0.76 | HPGD (0.46) | HPGDTSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041642-A1 | UREA INHIBITORS OF MAP KINASES | MAP4K2, MAP3K1, MAP3K20 | ALDH1A1 3577/4885HPGD 819/4885TSHR 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.