Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.73 |
| ▸ | BCR | P11274 | 11/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.73 |
| ▸ | PRKCA | P17252 | 3/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | BTK | Q06187 | 1/20 | 0.67 |
| ▸ | ITK | Q08881 | 1/20 | 0.67 |
| ▸ | ABL2 | P42684 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 4/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13492335 | 0.91 | ABL1 (0.75) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492334 | 0.88 | ABL1 (0.74) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL27841120 | 0.87 | ABL1 (0.79) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492337 | 0.86 | ABL1 (0.74) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL3219529 | 0.86 | ABL1 (0.77) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492348 | 0.86 | ABL1 (0.73) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492488 | 0.85 | ABL1 (0.76) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL2004455 | 0.85 | PDGFRA (0.91) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL23246300 | 0.85 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL28812376 | 0.85 | PDGFRA (0.78) | ABL1BCRPDGFRAPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048539-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | PDGFRB, PDGFRA, KIT | ABL1 9/4885BCR 65/4885PDGFRA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.