SCHEMBL1349372

SCHEMBL1349372

Clc1cnc(I)c(Cl)n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30927454 1.00
SCHEMBL19785439 0.75
SCHEMBL22532537 0.75
SCHEMBL19261599 0.75
SCHEMBL13089936 0.75
SCHEMBL6027802 0.75
SCHEMBL20840676 0.70
SCHEMBL19124369 0.69 GOT1 (0.35)
SCHEMBL913739 0.68
SCHEMBL12902021 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2396337-B1 PREPARATION AND USE OF ZINC-AMIDES UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) 2016-07-13 EP claimed
CN-102395593-B Preparation and use of zinc amides LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) 2015-08-12 CN claimed
EP-2396337-A1 PRODUCTION AND USE OF ZINC AMIDES Ludwig-Maximilians-Universität München (DE) 2011-12-21 EP claimed
US-20110288296-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2011-11-24 US claimed
WO-2010092096-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2010-08-19 WO claimed
US-12527325-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2026-01-20 US disclosed
WO-2025111408-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY AND HUNTINGTON'S DISEASE BIOGEN MA INC. (US) 2025-05-30 WO disclosed
US-20250084064-A1 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS MERCK SHARP & DOHME LLC (US) 2025-03-13 US disclosed
WO-2025051214-A1 AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR 上海翊石医药科技有限公司 2025-03-13 WO disclosed
US-12195445-B2 2-amino-N-heteroaryl-nicotinamides as Nav1.8 inhibitors MERCK SHARP & DOHME LLC (US) 2025-01-14 US disclosed
CN-113272293-B 2-Amino-N-heteroaryl-nicotinamide as NAV1.8 inhibitor 默沙东有限责任公司 2024-06-14 CN disclosed
WO-2023205173-A1 SUBSTITUTED PIPERIDINES AND SUBSTITUTED TETRAHYDROPYRIDINES AS IMMUNE-MODULATING COMPOUNDS BLACKSMITH MEDICINES, INC. (US) 2023-10-26 WO disclosed
US-20110288296-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2011-11-24 US disclosed
US-20110288296-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2011-11-24 US disclosed
US-20110288296-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2011-11-24 US disclosed
WO-2010092096-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2010-08-19 WO disclosed
WO-2010092096-A1 PRODUCTION AND USE OF ZINC AMIDES LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2010-08-19 WO disclosed
US-20100204230-A1 PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS MERCK SHARP & DOHME CORP. 2010-08-12 US disclosed
EP-2121633-A2 PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS Merck & Co., Inc. (US) 2009-11-25 EP disclosed
WO-2008099210-A2 PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS MERCK & CO., INC. (US) 2008-08-21 WO disclosed