Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.77 |
| ▸ | AR | P10275 | 3/20 | 0.77 |
| ▸ | IL6 | P05231 | 7/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571729 | 1.00 | NR3C1 (0.77) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12271690 | 1.00 | NR3C1 (0.77) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL16252266 | 1.00 | NR3C1 (0.77) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12272362 | 0.94 | NR3C1 (0.67) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12272191 | 0.94 | NR3C1 (0.67) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12272067 | 0.94 | NR3C1 (0.67) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12271925 | 0.94 | NR3C1 (0.67) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL2602748 | 0.91 | NR3C1 (0.72) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12431705 | 0.90 | NR3C1 (0.71) | NR3C1ARIL6KDM1ACFTR | |
| SCHEMBL12272803 | 0.89 | NR3C1 (0.70) | NR3C1ARIL6CFTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307375-B1 | PHENANTHRENONE COMPOUNDS, COMPOSITIONS AND METHODS | PFIZER (US) | 2014-11-19 | — | — | EP | disclosed |
| WO-2010013158-A1 | PHENANTHRENONE COMPOUNDS, COMPOSITIONS AND METHODS | PFIZER INC. (US) | 2010-02-04 | — | — | WO | disclosed |