Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.43 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436189 | 0.89 | APP (0.56) | APPPTGS2PTGS1MT-CO1MT-CO2 | |
| SCHEMBL11468007 | 0.82 | APP (0.64) | APPPTGS2PTGS1MT-CO1MT-CO2 | |
| Hexaprofen SCHEMBL2111016 | 0.81 | APP (0.67) | APPPTGS2PTGS1MT-CO1MT-CO2 | |
| SCHEMBL28176442 | 0.74 | BCL2L1 (0.42) | PTGS2PTGS1LMNACYP2C9ESR1 | |
| SCHEMBL14990594 | 0.74 | NAMPT (0.55) | HTT | |
| SCHEMBL13008860 | 0.74 | CYP19A1 (0.45) | PTGS1LMNACYP2C9TSHRHTT | |
| SCHEMBL11460427 | 0.74 | AKR1C3 (0.56) | APPPTGS2PTGS1AKR1C3SLC22A6 | |
| SCHEMBL14666799 | 0.73 | BCL2L1 (0.41) | PTGS2PTGS1LMNACYP2C9ESR1 | |
| SCHEMBL4397354 | 0.73 | ESR2 (0.38) | LMNACYP2C9ESR1KMT2ASLC18A3 | |
| SCHEMBL3133672 | 0.73 | ESR2 (0.62) | CYP2C9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019830-A1 | GLUCAGON ANTAGONISTS | METABASIS THERAPEUTICS, INC. (US) | 2010-02-18 | — | — | WO | disclosed |