Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ETV6 | P41212 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12403862 | 0.86 | AXL (0.53) | LRRK2AXLMAPK1GSK3BPIK3CA | |
| SCHEMBL20420387 | 0.85 | LRRK2 (0.52) | LRRK2MAPK1METKDRETV6 | |
| SCHEMBL15662422 | 0.84 | AXL (0.51) | LRRK2AXLKDRETV6GSK3B | |
| SCHEMBL3407553 | 0.84 | MAPK1 (0.48) | LRRK2AXLMAPK1GSK3BHTR2A | |
| SCHEMBL27852657 | 0.82 | MAPK1 (0.53) | LRRK2MAPK1MET | |
| SCHEMBL15661363 | 0.81 | AXL (0.48) | LRRK2AXLMAPK1GSK3BPIK3CD | |
| SCHEMBL13748883 | 0.79 | LRRK2 (0.61) | LRRK2MAPK1METKDRETV6 | |
| SCHEMBL11996741 | 0.79 | LRRK2 (0.61) | LRRK2MAPK1METKDRETV6 | |
| SCHEMBL15178476 | 0.76 | AXL (0.53) | AXLMAPK1GSK3BHTR2AHTR2C | |
| SCHEMBL15662906 | 0.76 | AXL (0.53) | AXLMAPK1GSK3BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260031-B1 | COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-10-07 | — | — | EP | disclosed |
| US-8716483-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-06 | — | — | US | disclosed |
| WO-2010021978-A2 | IL-8 BIOMARKER | SCHERING CORPORATION (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |