Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ETV6 | P41212 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11996741 | 0.89 | LRRK2 (0.61) | LRRK2MAPK1METNTRK1KDR | |
| SCHEMBL20420387 | 0.79 | LRRK2 (0.52) | LRRK2MAPK1METKDRETV6 | |
| SCHEMBL13495128 | 0.79 | LRRK2 (0.52) | LRRK2MAPK1METKDRETV6 | |
| SCHEMBL27852657 | 0.76 | MAPK1 (0.53) | LRRK2MAPK1MET | |
| SCHEMBL29643985 | 0.76 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL22890316 | 0.76 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL23207731 | 0.72 | NTRK1 (0.52) | LRRK2MAPK1NTRK1MAPK3 | |
| SCHEMBL2277926 | 0.72 | LRRK2 (0.57) | LRRK2MAPK1MAPK3 | |
| SCHEMBL11996761 | 0.72 | LRRK2 (0.57) | LRRK2MAPK1MAPK3 | |
| SCHEMBL17144260 | 0.72 | LRRK2 (0.57) | LRRK2MAPK1METMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |