Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748900 | 0.85 | LRRK2 (0.60) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL13495128 | 0.84 | LRRK2 (0.52) | MAPK1LRRK2AXLGSK3BHTR2A | |
| SCHEMBL3410414 | 0.83 | TTK (0.50) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL4222590 | 0.78 | AXL (0.55) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL12374209 | 0.77 | MAPK13 (0.38) | MAPK1LRRK2AXLMAPK13MAPK12 | |
| SCHEMBL2473158 | 0.76 | AXL (0.52) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL469901 | 0.75 | GABRP (0.39) | LRRK2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL15178439 | 0.75 | AXL (0.51) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL12193658 | 0.73 | MKNK1 (0.61) | MAPK1LRRK2AXLGSK3BAURKA | |
| SCHEMBL1663211 | 0.72 | AXL (0.60) | MAPK1AXLGSK3BAURKAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260031-B1 | COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-10-07 | — | — | EP | disclosed |
| US-8716483-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2260031-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | Schering Corporation (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |