SCHEMBL13495283

SCHEMBL13495283

C[C@@H]1CN(CC[C@@H](C(=O)N2CC(F)(F)C2)N2CCN(c3ccc(Cl)c(Cl)c3)CCC2=O)CCC12CC2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADAMTS5 Q9UNA0 6/20 0.38
HTR1A P08908 2/20 0.36
MAPT P10636 3/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
MMP2 P08253 3/20 0.35
MMP13 P45452 1/20 0.35
ADAM17 P78536 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
RAB9A P51151 1/20 0.35
TP53 P04637 1/20 0.35
PANK3 Q9H999 1/20 0.35
CCR1 P32246 1/20 0.35
HTR2A P28223 1/20 0.34
HTR7 P34969 1/20 0.34
HTR6 P50406 1/20 0.34
HIF1A Q16665 1/20 0.34
NOTUM Q6P988 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL736030 0.91 ADAMTS5 (0.38) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL736029 0.91 ADAMTS5 (0.38) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL13495289 0.86 MAPT (0.40) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL13495229 0.84 NPY5R (0.36) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL735214 0.82 HTR1A (0.40) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL735213 0.82 HTR1A (0.40) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL737154 0.80 HTR1A (0.40) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL737155 0.80 HTR1A (0.40) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL736078 0.80 HTR1A (0.37) ADAMTS5HTR1AMAPTMAPK1HTT
SCHEMBL736077 0.80 HTR1A (0.37) ADAMTS5HTR1AMAPTMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010012619-A1 DIAZEPAN AND PIPERAZINE DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2010-02-04 WO disclosed