Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10178084 | 0.81 | HTR6 (0.54) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL13495466 | 0.77 | MEN1 (0.47) | HTR6DRD3DRD2CYP11B1CYP11B2 | |
| SCHEMBL17064137 | 0.76 | MEN1 (0.62) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL17064153 | 0.76 | HTR6 (0.57) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL13302143 | 0.76 | MAPT (0.54) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL17070599 | 0.76 | MEN1 (0.62) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL12053364 | 0.73 | MEN1 (0.73) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL13495476 | 0.70 | PDE4A (0.47) | HTR6DRD3DRD2MEN1KMT2A | |
| SCHEMBL28126262 | 0.69 | HTR6 (0.59) | HTR6CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL26005660 | 0.69 | MAPT (0.63) | HTR6DRD3CYP11B1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017827-A1 | 6-SUBSTITUTED 1-SULFONYL-2, 3-DIHYDRO-INDOLE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2010-02-18 | — | — | WO | disclosed |