Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | HPD | P32754 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495694 | 0.87 | NR1H2 (0.47) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL13495669 | 0.86 | PTGS2 (0.51) | NR1H2NR1H3ALDH3A1 | |
| SCHEMBL2507591 | 0.82 | PIK3CD (0.61) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL2507006 | 0.82 | PIK3CD (0.61) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL13495645 | 0.80 | POLB (0.41) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL13495667 | 0.80 | GLA (0.48) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL3052790 | 0.80 | MAPK1 (0.65) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL13495668 | 0.78 | GSR (0.43) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL2508086 | 0.78 | PIK3CD (0.61) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG | |
| SCHEMBL2507590 | 0.78 | PIK3CD (0.61) | NR1H2NR1H3PIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010012745-A2 | BENZIMIDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | WO | disclosed |