Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | JAK1 | P23458 | 10/20 | 0.68 |
| ▸ | ULK1 | O75385 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907129 | 0.84 | ROCK2 (0.60) | JAK2JAK1ULK1 | |
| SCHEMBL4780688 | 0.84 | JAK2 (0.50) | JAK2JAK1KDM4EALDH1A1LMNA | |
| SCHEMBL12907294 | 0.83 | JAK2 (0.59) | JAK2JAK1ULK1 | |
| SCHEMBL4781046 | 0.82 | JAK2 (0.48) | JAK2JAK1ULK1KDM4EALDH1A1 | |
| SCHEMBL117222 | 0.81 | JAK2 (0.64) | JAK2JAK1ULK1KDM4EALDH1A1 | |
| SCHEMBL4783157 | 0.81 | JAK2 (0.47) | JAK2JAK1KDM4EALDH1A1LMNA | |
| SCHEMBL12907509 | 0.81 | MAPK1 (0.71) | JAK2JAK1 | |
| SCHEMBL12907343 | 0.81 | MAPK1 (0.58) | JAK2JAK1ULK1 | |
| SCHEMBL4404641 | 0.80 | JAK2 (0.58) | JAK2JAK1ULK1PDPK1CCNC | |
| Hydrochloric Acid SCHEMBL17206177 | 0.80 | JAK2 (0.62) | JAK2JAK1ULK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020307-A2 | INDAZOLE-5-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |