Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.58 |
| ▸ | JAK1 | P23458 | 8/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 3/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404646 | 0.86 | PDPK1 (0.51) | JAK2JAK1PDPK1KIF11 | |
| SCHEMBL4403644 | 0.85 | MAP2K4 (0.49) | JAK2JAK1HTR1AHTR1DHTR1B | |
| SCHEMBL117222 | 0.84 | JAK2 (0.64) | JAK2JAK1PDPK1ULK1CCNC | |
| Hydrochloric Acid SCHEMBL17206177 | 0.83 | JAK2 (0.62) | JAK2JAK1PDPK1ULK1CCNC | |
| SCHEMBL16308650 | 0.83 | KIF11 (0.50) | JAK2JAK1HTR1AHTR1DHTR1B | |
| SCHEMBL14380115 | 0.83 | JAK2 (0.51) | JAK2JAK1PDPK1ULK1CCNC | |
| SCHEMBL16929779 | 0.82 | JAK2 (0.58) | JAK2JAK1PDPK1ULK1KIF11 | |
| SCHEMBL10240133 | 0.82 | JAK2 (0.58) | JAK2JAK1PDPK1ULK1CCNC | |
| SCHEMBL16125483 | 0.81 | KIF11 (0.45) | JAK2JAK1PDPK1CCNCCDK8 | |
| SCHEMBL4407745 | 0.81 | PRKAB2 (0.47) | JAK2JAK1HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2011058474-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |