⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27757508 | 0.98 | PNMT (0.38) | — | |
| SCHEMBL4114428 | 0.93 | PNMT (0.38) | — | |
| Hydrochloric Acid SCHEMBL20837912 | 0.91 | PNMT (0.36) | — | |
| SCHEMBL6989045 | 0.86 | — | — | |
| SCHEMBL6512096 | 0.71 | PNMT (0.47) | — | |
| SCHEMBL8195075 | 0.71 | USP2 (0.42) | — | |
| SCHEMBL2048095 | 0.70 | — | — | |
| SCHEMBL8871757 | 0.70 | PNMT (0.36) | — | |
| SCHEMBL9038779 | 0.68 | RAB9A (0.51) | — | |
| SCHEMBL2043642 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11130766-B2 | Deuterated thienopiperidine derivatives, manufacturing method, and application thereof | JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. (CN) | 2021-09-28 | — | — | US | claimed |
| US-20210179632-A1 | THIENOPIPERIDINE DERIVATIVE AND USE THEREOF | JIANGSU TASLY DIYI PHARMACEUTICAL CO LTD (CN) | 2021-06-17 | — | — | US | claimed |
| EP-3048108-B1 | THIENOPIPERIDINE DERIVATIVE AND USE THEREOF | JIANGSU TASLY DIYI PHARMACEUTICAL CO LTD (CN) | 2020-07-15 | — | — | EP | claimed |
| CN-107922448-B | Deuterated thienopiperidine derivative, preparation method and application thereof | 江苏天士力帝益药业有限公司 | 2020-06-12 | — | — | CN | claimed |
| EP-3315505-B1 | DEUTERATED THIENOPIPERIDINE DERIVATIVES, MANUFACTURING METHOD, AND APPLICATION THEREOF | JIANGSU TASLY DIYI PHARMACEUTICAL CO LTD (CN) | 2020-03-25 | — | — | EP | claimed |
| US-10154992-B2 | Compounds and methods for treating HIV infection | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-12-18 | — | — | US | claimed |
| US-20180179222-A1 | DEUTERATED THIENOPIPERIDINE DERIVATIVES, MANUFACTURING METHOD, AND APPLICATION THEREOF | JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD. (CN) | 2018-06-28 | — | — | US | claimed |
| EP-3315505-A1 | DEUTERATED THIENOPIPERIDINE DERIVATIVES, MANUFACTURING METHOD, AND APPLICATION THEREOF | Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. (CN) | 2018-05-02 | — | — | EP | claimed |
| EP-2336315-B1 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION AS (DK) | 2017-07-19 | — | — | EP | claimed |
| EP-3048108-A1 | THIENOPIPERIDINE DERIVATIVE AND USE THEREOF | Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. (CN) | 2016-07-27 | — | — | EP | claimed |
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2004-07-01 | — | — | US | claimed |
| US-6432970-B2 | REDUCE CELL SENSITIVITY | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2002-08-13 | — | — | US | claimed |
| JP-2002511415-A | — | — | 2002-04-16 | — | — | JP | claimed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | claimed |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. | 2001-10-25 | — | — | US | claimed |
| EP-1143961-A2 | REGULATORS OF THE PTC OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Ontogeny, Inc. (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | claimed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | claimed |