Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pazelliptine SCHEMBL29376377 | 0.93 | KIT (0.73) | KITPDGFRAFGFR3BRAFNQO1 | |
| Pazelliptine SCHEMBL62441 | 0.93 | KIT (0.73) | KITPDGFRAFGFR3BRAFNQO1 | |
| Pazelliptine SCHEMBL1230910 | 0.92 | KIT (0.72) | KITPDGFRAFGFR3BRAFNQO1 | |
| Pazelliptine SCHEMBL1230570 | 0.91 | KIT (0.71) | KITPDGFRAFGFR3BRAFNQO1 | |
| SCHEMBL2311857 | 0.87 | KIT (0.65) | KITPDGFRAFGFR3ATAD2NPSR1 | |
| SCHEMBL12387163 | 0.84 | KIT (0.61) | KITPDGFRAFGFR3BRD4ATAD2 | |
| SCHEMBL2308783 | 0.83 | KIT (0.59) | KITPDGFRAFGFR3BRAFBRD4 | |
| SCHEMBL1065037 | 0.80 | KIT (0.78) | KITPDGFRAFGFR3BRAFNQO1 | |
| SCHEMBL2309766 | 0.80 | KIT (1.00) | KITPDGFRAFGFR3BRAFNQO1 | |
| SCHEMBL13596789 | 0.79 | KIT (1.00) | KITPDGFRAFGFR3BRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041617-A1 | Modulating mxa expression | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2010-02-18 | — | — | US | disclosed |
| US-20100041617-A1 | Modulating mxa expression | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041617-A1 | Modulating mxa expression | IRF3, ZC3HAV1, MAVS | KIT 3429/4885PDGFRA 2956/4885FGFR3 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.