Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22517096 | 0.90 | HTR2C (0.43) | OPRD1ACHEHTR2CHTR2BDRD2 | |
| SCHEMBL16543139 | 0.87 | OPRD1 (0.47) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL18616366 | 0.87 | OPRD1 (0.47) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL16543141 | 0.87 | OPRD1 (0.47) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL3236376 | 0.81 | HTR2A (0.46) | ACHEHTR2CDRD2SLC6A2HTR2A | |
| SCHEMBL1726880 | 0.81 | OPRD1 (0.45) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL4517111 | 0.81 | OPRD1 (0.45) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL1726878 | 0.81 | OPRD1 (0.45) | OPRD1ACHEESR1ESR2 | |
| SCHEMBL3538029 | 0.79 | HRH3 (0.46) | OPRD1DRD2HTR2A | |
| SCHEMBL4523079 | 0.77 | OPRD1 (0.37) | OPRD1ACHEESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662811-B2 | N-(((5R)-5-((1-methylethyl)amino)-5,6,7,8-tetrahydro-2-naphthalenyl)methyl)-2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-1,2,3,4-tetrahydro-2-pyrazinyl)acetamide; for treatment of pain and diseases, such as inflammation mediated diseases | AMGEN INC. (US) | 2010-02-16 | — | — | US | disclosed |